INNOVATION STARTS
WITH A SINGLE CELL
Raleigh Biosciences is utilizing single cell gene expression to advance plant biology research
OUR MISSION
We seek to revolutionize the agricultural industry through targeted control of gene expression, and to expedite crop development for sustainable food production.
ABOUT US
A gene discovery company, founded in 2023 to help the plant science community utilize single cell sequencing
OUR TECHNOLOGY
Utilizing single cell and spatial transcriptomics to precisely control gene expression and improve crop design
OUR SERVICES
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Single-Cell Transcriptomics
Single-cell gene expression profiles
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Spatial Transcriptomics
Spatially resolved gene expression
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Gene Expression Atlas
Comprehensive map of gene expression
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Genome Editing
Genome editing at promoters to control gene expression in specific cell types
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AI-Driven Models
These models predict genome features and synthetic promoter constructs to drive transgene expression
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3D Cellular Printing
This technique allows for elite
germline transformation and faster screening of traits
RALEIGH BIOSCIENCES IN THE NEWS
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Prediction and functional characterization of transcriptional activation domains
Mahatma et al. leveraged a neural network approach to systematically predict transcription factor activation domains. The findings further highlight the importance of aromatic and negatively charged amino acids and reveal…
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Functional Annotation of Proteins for Signaling Network Inference in Non-Model Species
Van den Broeck et al. developed a multi-layer neural network that annotates proteins by determining functionality directly from the protein sequence and enabled de novo identification of kinase-substrate interactions.
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Establishing a Reproducible Approach to Study Cellular Functions of Plant Cells with 3D Bioprinting
Van den Broeck et al. established a framework for 3D bioprinting plant cells to study cell viability, cell division, and cell identity. The framework established paves the way for a general use of 3D bioprinting for studying cellular reprogramming and…
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Single-Cell Genomics Revolutionizes Plant Development Studies Across Scales
This review highlights some of the technical developments and how they have led to profiling single-cell genomics in various plant organs. Zhu et al. emphasize the contribution of single-cell genomics in revealing developmental trajectories….
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Protocol for Fast scRNA-seq Raw Data Processing Using scKB and Non-Arbitrary Quality Control with COPILOT
Hsu et al. describe a protocol to perform fast and non-arbitrary quality control of single-cell RNA sequencing (scRNA-seq) raw data using scKB and COPILOT. This protocol streamlines the processing workflow and provides an easy entry for…
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A Single-Cell Arabidopsis Root Atlas Reveals Developmental Trajectories in Wild-Type and Cell Identity Mutants
Using scRNA-seq, Shahan and Hsu et al. produced an Arabidopsis root atlas, revealing gradual gene expression changes underlying differentiation of cell types and candidate regulators of cell fate. The atlas enabled interpretation of smaller…
